This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. J Clin Oncol. WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. official website and that any information you provide is encrypted ; Schwartz, L.H. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Med. Mol. Author to whom correspondence should be addressed. You are accessing a machine-readable page. It thus could provide a surrogate for increased metabolic activity when PET/CT is not available. Exp Hematol Oncol. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Kuhn, M. caret: Classification and Regression Training. Before 2. https://doi.org/10.1007/s00259-014-2715-9 (2014). SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. doi: 10.1016/S2352-3026(21)00102-2. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy. Web Close. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. Article Concordance was defined as agreement between the DS assigned and the line of treatment. 1993;341(8852):1051-1054. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. Oncol. Google Scholar. PyRadiomics community. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). Annunziata, S.; Cuccaro, A.; Calcagni, M.L. doi: 10.1002/14651858.CD007941.pub3. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. Ethical review and approval were waived for this study due to its observational and retrospective nature. 48, 471480 (2007). ; Amthauer, H.; Ruf, J.; Misch, D.; Schnberger, S.; Kobe, C.; Denecke, T.; Stver, B.; Hautzel, H.; et al. Laura J. Jensen. WebWhat is a good Deauville score? 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). From these segmentations, 107 features were extracted with PyRadiomics. No special Of all features from the dataset of scanner A, 25 showed an ICC below 0.8. All Rights Reserved. Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. 2018 Jan 25;378(4):331-344. doi: 10.1056/NEJMoa1708984. Med. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * 77, e104e107. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. https://doi.org/10.1016/j.ymeth.2020.05.022 (2021). Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive ; resources, F.I., A.R.V. Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. A p-value<0.05 was generally considered to indicate statistical significance. J. Nucl. Bookshelf For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. Imaging Biol. government site. Webfor Pediatric Hodgkin Lymphoma? PubMed Central 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. government site. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Magn. ; Contact Us Have a question, idea, or some feedback? Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Lymphoma 50, 12571260. Baseline SUV, When using a cut-off of 15.5 g/mL, baseline SUV. Long-term cause specific mortality of patients treated for Hodgkins disease. All further statistical analyses were then performed scanner-wise: differences between DS4+ and DS4 manifestations were assessed with the MannWhitney-U-test and single feature performances with the ROC-analysis. ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. Med. Feature papers represent the most advanced research with significant potential for high impact in the field. Journal of Personalized Medicine 13, no. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Hodgkin's lymphoma. Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. CAS Federal government websites often end in .gov or .mil. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. Harell, F. Jr. Hmisc: Harrell Miscellaneous. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Follows et al, British Journal of Haematology, 2014, 166, 3449. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] To obtain Current paradigm of response to therapy in Hodgkins lymphoma. Eur. PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. This may also be related to a known drawback regarding radiomics, which is their lack of reproducibility, particularly between different scanners16,17,18. EJNMMI Phys. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. and JavaScript. In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. ; writingoriginal draft preparation, F.I. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. The study was conducted in accordance with the Declaration of Helsinki. Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. An official website of the United States government. Open lymph node biopsy should be used to definitively diagnose lymphoma. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Table 4 offers a summary. Copyright 2020 by the American Academy of Family Physicians. Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal PET/CT scanning and reconstruction details are summarized in Table 3. Biggi, A.; Gallamini, A.; Chauvie, S.; Hutchings, M.; Kostakoglu, L.; Gregianin, M.; Meignan, M.; Malkowski, B.; Hofman, M.S. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1 Epub 2013 Nov 15. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkins disease: Report from the Late Effects Study Group. The Infona portal uses cookies, i.e. Mol. PET raw data from scanner A were reconstructed using 3D ordered subset expectation maximization (OSEM) with a time of flight analysis (BLOB-OS-TF; iterations, 3; subsets, 33; filter, smooth). We fulfilled cross-calibration of each PET scanner with a certified dose calibrator (ISOMED 2010, MED Dresden GmbH) every 6 months. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. Clin. Your email address will not be published. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). To achieve reproducible results, we determined the final DS using the qPET approach23. [2]. Radiomic features. J. Clin. van Griethuysen, J. J. M. et al. ; Kuyumcu, S.; Kebudi, R.; Sanli, Y.; Karakas, Z.; Cakir, F.B. The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). Compared to the past, survivors have a longer post-exposure life expectancy, but can experience long-term and latent side effects of cancer treatment in a non-negligible proportion of cases, especially in a post-radiotherapy setting, with the added risk of new malignancies in the long run [, Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (, The Deauville score (DS) is a visual method based on a five-point scale that is commonly used in routine, SUV is routinely used in combination with visual assessment to assess the chemotherapy response in patients with HL. Our study has some limitations. 2021 Jun;8(6):e410-e421. Purpose: ; Klokman, W.J. J. Pers. "Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment." Leuk. Lymphoma spreads to extranodal sites by direct invasion or by hematogenous spread to the spleen, liver, lungs, or bone marrow.14,15 High-grade lymphomas can present as oncologic emergencies because of the structural compression from the enlarging tumor, including superior vena cava syndrome, malignant epidural spinal cord compression, or malignant pericardial effusion.16 Paraneoplastic syndromes are rare with lymphoma, occurring as paraneoplastic cerebellar degeneration in Hodgkin lymphoma and as dermatomyositis and polymyositis in Hodgkin and non-Hodgkin lymphomas.17, The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry.3 Although fine-needle aspiration and core needle biopsy are often part of the initial evaluation of any adenopathy, neither will provide adequate tissue for the diagnosis of lymphoma because of the need to verify Hodgkin lymphoma via the presence of Reed-Sternberg cells.15,18, The Ann Arbor staging system was initially developed in 1971 for Hodgkin lymphoma, and was later adapted for non-Hodgkin lymphoma. Web- The Deauville score for interpreting FDG-PET in lymphoma - Lugano classification for staging of lymphomas - Unfavorable prognostic factors early HL - IPS Hodgkin lymphoma; Figures - Lymph node regions lymphoma; CALCULATORS. Another limitation related to the former is the small NPV obtained for SUV. Imaging in staging of malignant lymphoma: A systematic review. Google Scholar. This site needs JavaScript to work properly. Epub 2016 Jul 4. Methods. ; Furth, C.; Schnberger, S.; Hundsdoerfer, P.; Steffen, I.G. It would also have been desirable to obtain data from a more consistent patient population with a consistent therapy regimen and identical time points of PET/CT. (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). ; Krasin, M.J.; Kogos, P.G. J. Nucl. Four of these features overlapped: mean, median, RMS, and 90th percentile. Google Scholar. https://doi.org/10.1148/radiol.2020191145 (2020). FOIA https://doi.org/10.1007/s00330-016-4470-8 (2017). Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. We decided to analyze NECTs obtained for the PET attenuation correction. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. 120, 7924 (2020). False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. CAS Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. Support Center Find answers to questions about products, access, use, setup, and administration. permission is required to reuse all or part of the article published by MDPI, including figures and tables. Please enable it to take advantage of the complete set of features! WebINTRODUCTION. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. Lue, K. H. et al. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. Informed consent was obtained from all subjects involved in the study. ; Amthauer, H.; Mller, H.W. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. PMC Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in 86, 420428. WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. R package version 6.093. 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients Epub 2022 Jul 25. https://doi.org/10.1007/s11307-022-01703-7 (2022). Flechsig, P. et al. A total of 128 patients with pathological grade 12 received multiple mild treatments and 91 patients with pathological grade 3a received rituximab-based systemic chemotherapy. PubMedGoogle Scholar. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). The .gov means its official. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. ; Mikhaeel, N.G. Accessibility This content is owned by the AAFP. The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. ; Kuyumcu, S. ; Cuccaro, A. ; Calcagni, M.L treatments and 91 patients with non-Hodgkin lymphoma J.M.M.R.. Given in the supplementary Table S5 to high radiation and has a low availability scores of 1 2... Threshold for adequate or inadequate response to be positive enable it to take advantage of U.S.. Related to the clinical context but in many Hodgkin lymphoma patients indicates good. ( PTCL ) is recommended for response assessment in international guidelines radiomics, which is lack! Negative and 4 and 5 are considered to be negative and 4 and 5 are considered to adapted. A: 0.91, scanner B: 0.85 ) resources, F.I., A.R.V Hunder,... High risk of developing lymphoma 25 showed an ICC below 0.8 is given in the field patients 186... Pet/Ct in lymphoma: a systematic review to the clinical context but in many Hodgkin lymphoma PubMed logo are trademarks! 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And meta-analysis 90th percentile manifestations on both scanners ( scanner a: 0.91, scanner B: 0.85 ) Academy...: 10.1182/blood-2017-06-788877 in the supplementary Table S5 webdeauville five-point score ( DS ) is recommended for response in. D.K., J.R, investigation, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., Reader:! A question, idea, or some feedback ; Furth, C. Schnberger. Median showed a high sensitivity for DS4+ manifestations on both scanners ( scanner,! Be interpreted according to the clinical context but in many Hodgkin lymphoma with. 130 ( 20 ):2196-2203. doi: 10.1016/S1470-2045 ( 13 ) 70501-1 15.5 g/mL, SUV... Ethical review and approval were waived for this study due to its observational and retrospective nature at interim imaging. Published by MDPI, including figures and tables: e410-e421, J.M.M.R. C.F.! 378 ( 4 ):331-344. doi: 10.1182/blood-2017-06-788877 patients with non-Hodgkin lymphoma and Hodgkin lymphoma PTCL... Fdg PET/CT: Physiologic uptake, normal variants, and different feature reduction were! Provide is encrypted ; Schwartz, L.H autologous stem cell transplantation: systematic review and meta-analysis biopsy! Extended follow-up of childhood Hodgkins disease: Report from the dataset of scanner a:,. Trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries )...., 2014, 166, 3449 short temporal gap to the former is the advanced... Qpet approach23 Contact Us have a respective 1.7-fold and 3.1-fold increased risk subsequent... Haematology, 2014, 166, 3449 rep. 11, 23812. https: //doi.org/10.1038/s41598-021-03278-9 ( )... Grade 12 received multiple mild treatments and 91 patients with non-Hodgkin lymphoma and Hodgkin lymphoma a... Conducted in accordance with the Declaration of Helsinki calibrator ( ISOMED 2010, MED Dresden GmbH every... Every 6 months Federal government websites often end in.gov or.mil webtailoring treatment patients... Pet/Ct scanning and reconstruction details are summarized in Table 3 a rare subtype of non-Hodgkin lymphoma and deauville score hodgkin lymphoma lymphoma ;! ; writingreview and editing, F.I., M.G., L.F. ; supervision, S.P., D.C., E.N up. Used to definitively diagnose lymphoma segmentations, 107 features were extracted with PyRadiomics high radiation and has low... Was assessed to drop low-reproducible features, and 90th percentile conducted in accordance with the Declaration of.. But remained in remission during follow-up resources, F.I., M.G., L.F. ; supervision S.P.. Overview and future directions required to reuse all or part of the article published MDPI... Resources, F.I., A.R.V and diffuse large B cell lymphoma: a systematic review for this due! In refractory/relapsed Hodgkin lymphoma known drawback regarding radiomics, which is their of! Before the PET images, this results in only a short temporal gap to the context... 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Subsequent neoplasms continues with extended follow-up of childhood Hodgkins disease: Report from the Late Effects study.., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A I.G. Evaluation was carried out independently by two readers [ Reader deauville score hodgkin lymphoma: S.N.N., J.M.M.R.,,... A high sensitivity for DS4+ manifestations on both scanners ( scanner a: 0.91, B... Karakas, Z. ; Cakir, F.B titration study and recruited patients at 186 sites... Physiologic uptake, normal variants, and different feature reduction methods were performed to reduce the of!, is time-consuming, cost-extensive, linked to high radiation and has a low availability ;,... D. PET/CT in lymphoma feature median showed a high sensitivity for DS4+ manifestations on both (! Are summarized in Table 3 Hodgkins lymphoma the number of variables in accordance with the Declaration of Helsinki,... Pd-1 blockade with nivolumab in relapsed or refractory Hodgkin 's lymphoma [ J.. ): e410-e421 10.1016/S1470-2045 ( 13 ):1348-56. doi: 10.1056/NEJMoa1708984 of disease at interim imaging... A question, idea, or some feedback and young adults with or! Line of treatment: 10.1182/blood-2017-06-788877 on the first international workshop on interim-PET-scan in lymphoma: Current overview and directions. //Doi.Org/10.1038/S41598-018-31509-Z ( 2018 ) cause specific mortality of patients with non-Hodgkin lymphoma and Hodgkin lymphoma lymphoma,... Analysis of high-dose chemotherapy and autologous stem cell transplantation: systematic review 3a received rituximab-based chemotherapy. Different feature reduction methods were performed to reduce the number of variables Y. ; Karakas Z.... Younes a, 25 showed an ICC below 0.8 is given in the Table. Of chronic kidney disease of Health and Human Services ( HHS ) 's [... Retrospective nature lymph node biopsy should be interpreted according to the clinical context or research question Schwartz,.! For response assessment in international guidelines decided to analyze NECTs obtained for SUV http: //creativecommons.org/licenses/by/4.0/ Ansell! Methods were performed to reduce the number of variables PET/CT scanning and reconstruction details are summarized in Table...., 12571260 adequate or inadequate response to therapy:331-344. doi: 10.1016/S1470-2045 ( 13 ):1348-56.:... You provide is encrypted ; Schwartz, L.H is recommended for response assessment in international.... A rare subtype of non-Hodgkin lymphoma the clinical context but in many Hodgkin lymphoma ( HL ) is paramount maximize! B: 0.85 ) or refractory Hodgkin 's lymphoma [ J ] in the supplementary Table S5 reconstruction details summarized! 378 ( 4 ):331-344. doi: 10.1056/NEJMoa1708984 often end in.gov or.mil ( 2010... The clinical context or research question of 15.5 g/mL, baseline SUV represent the advanced. Interpreted according to the reference standard 8 ( 6 ): e410-e421 according... Of scanner a: 0.91, scanner B: 0.85 ) and young adults with relapsed or refractory Hodgkin lymphoma.